NAC is well tolerated, even at very high doses.
NAC appears to be protective before brain injury (good for those who put their brains at risk).
After injury, NAC appears to improve outcomes for TBI survivors.
1. NAC (200mg/kg) provided marked neuroprotection with up to 78% reduction of brain injury
Wang, X., Svedin, P., Nie, C., Lapatto, R., Zhu, C., Gustavsson, M., . . . Mallard, C. (2007). N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Annals of Neurology, 61(3), 263-271. doi:10.1002/ana.21066
NAC (200mg/kg) provided marked neuroprotection with up to 78% reduction of brain injury in the pre+post-HI treatment group and 41% in the early (0 hour) post-HI treatment group, which was much more pronounced protection than another free radical scavenger, melatonin. Protection by NAC was associated with the following factors: (1) reduced isoprostane activation and nitrotyrosine formation; (2) increased levels of the antioxidants glutathione, thioredoxin-2, and (3) inhibition of caspase-3, calpain, and caspase-1 activation.
More information about NAC, listen to my mentor in clinical nutrition: