Phosphatidylcholine Powder

From The Concussion Repair Manual by Dr. Dan Engle, MD

Every cell of the body wraps the inner environment of the cell in a protective outer coat comprised of phospholipids. Phosphatidylserine (PS) and Phosphatidylcholine (PC) are part of the family of phospholipids, and play an essential role in neuronal survival and recovery following injury. We find PS concentrated at key protein receptor docks on cell membranes. Proteins that land here communicate with the cell by activating chemical signals within. Survival of a neuron depends on these chemical messengers. These messengers are responsible for growth and regeneration of the neuron, in addition to function of the synapse. Recal that the synapse is where the neuron synthesizes and releases neurotransmitters.


We find that higher concentrations of PS correlate with higher levels of neurotransmitters acetylcholine, norepinephrine, serotonin, and dopamine. Phosphatidylserine (PS) also helps the body adapt to stress by reducing cortisol output. Following TBI, many suffer from PTSD and chronic anxiety. The body and brain struggle with releasing trauma, and many TBI survivors suffer from a chronic state of stress. PS helps reduce the damaging effects of stress on the brain. It also enhances our tolerance of stress, and reduces cortisol output by the adrenals. I consider PS an essential nutrient for repairing brain function and adrenal recovery following trauma. Phosphatidylcholine (PC) serves as a phospholipid reserve that can be tapped when PS concentrations drop. The process is metabolically demanding and requires a good supply of calcium and the amino acid serine. To reach the therapeutic doses required to optimize nerve function and healing, oral supplementation is highly recommended.

Also of interest, PS shows greater effectiveness when concentrations of DHA are high, which we acquire through fish oil [get high dose DHA fish oil here]. Other nutrients that enhance PS’s cell membrane function include fat-soluble antioxidants, such as astaxanthin and other carotenoids, vitamin E, and coenzyme-Q-10. Furthermore, Co-Q-10 not only supports cell membrane function, it also works as its own antioxidant and stimulates ATP production.

The suggested dose range for brain support and repair for PS is 500 – 1,000 mg taken at night before bed. The dosage range for PC is 800 – 2,400 mg per day.


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