Huperzine A is a Sesquiterpene Alkaloid found in Huperzia Serrata, a species of Firmoss native to India and Southeast Asia. Huperzia Serrata has seen a long history of use for its Huperzine A content in Traditional Chinese Medicine.


Recent advances in our knowledge on Huperzine A has shown that it has a plethora of benefits, that include enhancement of learning, memory, mood and it has even been shown to potently protect the brain from various stressors.



What makes Huperzine A special, is that it inhibits an enzyme called Acetylcholinesterase, which breaks down Acetylcholine. By inhibiting this enzyme, Acetylcholine levels will increase, however, many Acetylcholinesterase inhibitors inhibit various forms of this enzyme which cause an elevation of Acetylcholine levels in undesired regions of the brain and body. Huperzine A, in contrast, only inhibits the G4 isoform of Acetylcholinesterase, which selectively raises Acetylcholine levels in areas of the brain that play key roles in memory, learning and mood. Due to this, Huperzine can produce a subtle yet prominent elevation in memory, learning and mood without many of the undesirable effects of increased Acetlycholine levels such as Nausea and GI tract discomfort.

Another interesting thing about Huperzine A, is that via inhibiting the G4 Isoform of Acetylcholineesterase, it causes increased activation of Alpha 7 Nicotinic Acetylcholine receptors, which regulate, for a large part, inflammatory pathways in the brain. By causing increased activation of this receptor, Huperzine A supports balanced inflammation levels, which may protect the brain from damage, as a lot of damage in the brain is caused by uncontrolled inflammation. This can also have major effects on both mood and cognition.

200 mcg of Huperzine A is shown in  research to be one of the most efficacious dosages Huperzine A.


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