Curcuminoids with Piperine 

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Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective

Abstract: https://doi.org/10.1517/13543784.2011.542410
Paul A Lapchak , PhD FAHA
Pages 13-22 | Published online: 15 Dec 2010 | Download citation

Take home message: Curcumin and curcuminoids are neuroprotective in a variety of preclinical stroke models. The novel multi-target curcuminoid, CNB-001, has a superior safety and pharmacokinetic profile and should be further developed as an acute monotherapy or to be used in conjunction with thrombolytics for acute ischemic stroke.

Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R.

Abstract: https://doi.org/10.1016/j.mvr.2015.12.008
Li W, Suwanwela NC, Patumraj S.

Conclusion
The protective effects of curcumin against cerebral I/R injury reflect anti-oxidation, anti-inflammation and anti-apoptotic activities, resulting in the elevation of Nrf2 [a protein that can turn on the production of antioxidant enzymes] and down-regulation of NF-κB [an inflammatory sgnalling protein].

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

Abstract: https://doi.org/10.1016/j.pbb.2008.10.007
Pharmacology Biochemistry and Behavior
Volume 92, Issue 1, March 2009, Pages 39-43
Mohit Kumar Bhutani, Mahendra Bishnoi, Shrinivas K.Kulkarni

Abstract
…The combination of piperine (2.5 mg/kg, i.p., 21 days), a bioavailability enhancer, with curcumin (20 and 40 mg/kg, i.p., 21 days) showed significant potentiation of its anti-immobility, neurotransmitter enhancing (serotonin and dopamine) and monoamine oxidase inhibitory (MAO-A) effects as compared to curcumin effect per se. This study provided a scientific rationale for the use of curcumin and its co-administration with piperine in the treatment of depressive disorders