CITATION NOTES
Chapter 1
1 National Institute of Mental Health. “Any Mental Illness (AMI) Among U.S. Adults.” Accessed October 1, 2017, https://www.nimh.nih.gov/health/statistics/prevalence/any-mental-illness-ami-among-us-adults.shtml.
Chapter 2
1 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation (3rd ed.) (St. Louis: Saunders Elsevier Inc., 2007), 28-29.
2 Mason, Peggy. Medical Neurobiology (New York: Oxford University Press, 2011), 4
3 Doidge, Norman. The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science. (New York: Penguin Books, 2007), xvii-xix, 12-13.
4 Schwartz, Jeffrey M. and Sharon Begley. The Mind & The Brain: Neuroplasticity and the Power of Mental Energy. (New York: Harper Collins Publishers, Inc., 2003), chapter 1.
5 Doidge, Norman. The Brain That Changes Itself, xvii-xix, 12-13.
6 Ramachandran, V.S. preface to The Tell-Tale Brain: A Neuroscientist’s Quest for What Makes Us Human (New York: W. W. Norton & Company, Inc., 2011), xiii.
7 Doidge, Norman. Book description for The Brain That Changes Itself. Available at https://www.penguinrandomhouse.com/books/291041/the-brain-that-changes-itself-by-norman-doidge/9780670038305/.
8 Grant, Gunnar. “How the 1906 Nobel Prize in physiology or medicine was shared between Golgi and Cajal,” Brain Research Reviews 55.2 (2007): 490-98.
9 Schwartz, Jeffrey M. and Sharon Begley. The Mind & The Brain, chapter 1.
10 Schwartz, Jeffrey M. and Sharon Begley. The Mind & The Brain, chapter 1
11 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 71-83
12 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 4.
13 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 4-14.
14 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 28-30.
15 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 28-30.
16 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 39-42, 47.
17 Gómez-Pinilla, Fernando. “Brain foods: the effects of nutrients on brain function,” Nature Reviews Neuroscience 9.7 (2008): 568-578.
18 Bender, David A. Introduction to Nutrition and Metabolism (5th ed.) (Boca Raton,FL: CRC Press, 2014), 1-4.
19 Bender, David A. Introduction to Nutrition and Metabolism, 1-4.
20 Sherwood, Lauralee. Human Physiology: From Cells to Systems (9th ed.) (Boston: Cengage Learning, 2015), 566-72.
21 Drubach, Daniel. The Brain Explained (Upper Saddle River, NJ: Prentice Hall, 2000).
22 Brown, Guy. The Energy of Life: The Science of What Makes Our Minds and Bodies Work (New York: The Free Press, 1999).
23 Hart, Leslie A. How the Brain Works: A New Understanding of Human Learning, Emotion, and Thinking (New York: Basic Books,1975).
24 Wurtman, Richard J. and Judith J Wurtman. Nutrition and the Brain. Volume 2. Control of feeding behavior and biology of the brain in protein-calorie malnutrition (New York: Raven Press, 1977).
25 Youdim, Kuresh A. and James A Joseph. “A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects,” Free Radical Biology and Medicine 30.6 (2001): 583-94.
26 Azevedo, Frederico A.C., et. al. “Equal Numbers of Neuronal and Nonneuronal Cells Make the Human Brain an Isometrically Scaled-Up Primate Brain,” The Journal of Comparative Neurology 513 (2009):532–41. doi:10.1002/cne.21974.
27 Azevedo, Frederico A.C., et. al. “Equal Numbers of Neuronal and Nonneuronal Cells Make the Human Brain an Isometrically Scaled-Up Primate Brain” 532–41.
28 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 43-46.
29 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 44 .
30 Johnson, Victoria E., William Stewart, Douglas H.Smith. “Axonal pathology in traumatic brain injury,” Experimental Neurology 246 (August 2013): 35-43. Available online January 20, 2012. doi:10.1016/j.expneurol.2012.01.013.
31 Johnson, Victoria E., William Stewart, Douglas H.Smith.. “Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans,” Brain Pathology 22 (2) (March 2012): 142-49. doi:10.1111/j.1750-3639.2011.00513.x.
32 Masliah E , et al. “Cortical dendritic pathology in human immunodeficiency virus encephalitis,” Laboratory Investigation; a Journal of Technical Methods and Pathology 66(3) (01 Mar 1992): 285-91. doi:10.1001/archneur.61.3.369.
33 “Wikipedia “Organism” (12 Apr. 2016) Available at https://en.wikipedia.org/wiki/Organism, accessed on October 2, 2017.
34 Koshland, Daniel E. “The Seven Pillars of Life,” Science 295.5563 (2002): 2215-216.
35 Mayer, Emeran A. “Gut feelings: the emerging biology of gut–brain communication,” Nature Reviews Neuroscience 12.8 (2011): 453-66.
36 Kharrazian, Datis. Why Isn’t My Brain Working?: A revolutionary understanding of brain decline and effective strategies to recover your brain health(Carlsbad, CA: Elephant Press, 2013), 163-66.
37 Furness, John Barton, and Marcelo Costa. “Types of nerves in the enteric nervous system.” Neuroscience 5.1 (1980): 1-20.
38 Furness, John Barton and Marcelo Costa. The Enteric Nervous System. (London: Churchill Livingstone, 1987).
39 Permlutter, David E. Grain Brain:The Surprising Truth About Wheat, Carbs, and Sugar—Your Brain’s Silent Killers (New York: Little, Brown and Company, 2013), 190.
40 Gershon, Michael MD. The Second Brain: The Scientific Basis of Gut Instinct and a Groundbreaking New Understanding of Nervous Disorders of the Stomach and Intestines (New York: Harper, 1998).
41 Kim, Doe-Young, and Michael Camilleri. “Serotonin: a mediator of the brain-gut connection,” The American Journal of Gastroenterology 95.10 (2000): 2698.
42 Martin, MT, F Azpiroz, and JR Malagelada. “Melatonin and the gastrointestinal tract,” Thérapie 53.5 (1997): 453-58.
43 Messner, Michael et al. “Presence of melatonin in the human hepatobiliary-gastrointestinal tract,” Life Sciences 69.5 (2001): 543-51.
44 Kim, Doe-Young and Michael Camilleri. “Serotonin: a mediator of the brain-gut connection” 2698.
45 Martin, MT, F Azpiroz, and JR Malagelada. “Melatonin and the gastrointestinal tract.” 453-58.
46 Messner, Michael et al. “Presence of melatonin in the human hepatobiliary-gastrointestinal tract” 543-51.
47 Permutter, David E. Grain Brain, 178-81.
48 Bansal, Vishal et al. “Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis,” Journal of Neurotrauma 26.8 (2009): 1353-359.
49 Forsyth, Christopher B et al. “Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease,” PLOS ONE 6.12 (2011): e28032.
50 Mass, Michael, Marta Kubera, and Jean-Claude Leunis. “The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression,” Neuroendocrinology Letters 29.1 (2008): 117-24.
51 Bansal, Vishal et al. “Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis” 1353-359.
52 Forsyth, Christopher B et al. “Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease.” PLOS ONE 6.12 (2011): e28032.
53 Petra, Anastasia, et al. “Gut-Microbiota-Brain Axis and its Effect on Neuropsychiatric Disorders with Suspected Immune Dysregulation,” Clinical Therapeutics 37 (2015): 984-995.
54 Dunlop, Simon, et al. “Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes,” The American Journal of Gastroenterology 101 (2006):1288-294.
55 Jackson, P.G, et al. “Intestinal Permeability In Patients With Eczema And Food Allergy,” The Lancet (1981): 1285-286.
56 Jenkins, R., et al. “Increased Intestinal Permeability In Patients With Rheumatoid Arthritis: A Side-Effect Of Oral Nonsteroidal Anti-Inflammatory Drug Therapy?,” Rheumatology (1987): 103-07.
57 Visser, Jeroen, et al. “Tight Junctions, Intestinal Permeability, and Autoimmunity,” Annals of the New York Academy of Sciences (2009): 195-205
58 Fasano, Alessio. “Zonulin and Its Regulation of Intestinal Barrier Function: The biological Door to Inflammation, Autoimmunity, and Cancer,” Physiological Reviews 91.1 (2011): 151-75.
59 Arrieta MC, Bistritz L, Meddings JB. “Alterations in intestinal permeability,” Gut 55 (2006):1512-520.
60 Fasano, Alessio and Terez Shea-Donohue. “Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases.” Gastroenterology and Hepatology 2 (September 2005): 416-22. https://doi.org/10.1038/ncpgasthep0259.
61 Kharrazian, Datis. Why Isn’t My Brain Working?, 175-77.
62 Sherwood, Lauralee. Human Physiology, 566-72.
63 Arrieta MC, et al. “Alterations in Intestinal Permeability”1512-520.
64 Fasano, Alessio and Terez Shea-Donohue. “Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases” 416-22.
65 Arrieta MC, et al. “Alterations in intestinal permeability” 1512-520.
66 Fasano, Alessio and Terez Shea-Donohue. “Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases” 416-22.
67 Arrieta MC, et al. “Alterations in intestinal permeability” 1512-520.
68 Fasano, Alessio and Terez Shea-Donohue. “Mechanisms of Disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases” 416-22.
69 Kharrazian, Datis. Why Isn’t My Brain Working?, 175-77.
70 Wahls, Terry L. The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles (New York: Avery, 2014), 91.
71 Lundy-Ekman, Laurie. Neuroscience: Fundamentals for Rehabilitation, 495-97.
72 Wahls, Terry L. The Wahls Protocol, 91.
73 Kharrazian, Datis. Why Isn’t My Brain Working?, 204-208.
74 Banks, WA, AJ Kastin, and RD Broadwell. “Passage of cytokines across the blood-brain barrier,” Neuroimmunomodulation 2.4 (1995): 241-48.
75 Banks, WA, AJ Kastin, and RD Broadwell. “Passage of cytokines across the blood-brain barrier” 241-48.
76 Kharrazian, Datis. Why Isn’t My Brain Working?, 199-200.
77 Ekdahl, Christine T. et al. “Inflammation is detrimental for neurogenesis in adult brain,” Proceedings of the National Academy of Sciences 100.23 (2003): 13632-3637.
78 Nimmo, AJ et al. “Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats,” Neuropeptides 38.1 (2004): 40-47.
79 Moore, TC. “Modification of lymphocyte traffic by vasoactive neurotransmitter substances,” Immunology 52.3 (1984): 511.
80 Swank, Gregory M. and Edwin A Deitch. “Role of the gut in multiple organ failure: bacterial translocation and permeability changes,” World Journal of Surgery 20.4 (1996): 411-17.
81 Kharrazian, Datis. Why Isn’t My Brain Working?, 42-43, 101-02.
82 Swank, Gregory M. and Edwin A Deitch. “Role of the gut in multiple organ failure: bacterial translocation and permeability changes” 411-17.
83 Nimmo, AJ et al. “Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats,” Neuropeptides 38.1 (2004): 40-47.
84 Banks, WA, AJ Kastin, and RD Broadwell. “Passage of cytokines across the blood-brain barrier” 241-48.
85 Perlmutter, David E. Grain Brain, 61-62.
86 Kharrazian, Datis. Why Isn’t My Brain Working?, 36, 38, 42-43, 101-102, 175.
87 Perlmutter, David E. Grain Brain, 33, 61-62.
88 Kharrazian, Datis. Why Isn’t My Brain Working?, 36, 38, 175.
89 Perlmutter, David E. Grain Brain, 33, 51, 53, 61-62.
90 Dr. Tom O’Bryan has stated this in many interviews, articles, presentations, and podcasts. One example is available at: http://thedr.com/wp-content/uploads/2014/07/Top-3-Tips_Edit_073014.pdf (accessed on September 25, 2017).
91 O’Bryan, Tom. The Autoimmune Fix (New York: Rodale Inc., 2015), 59 (quoting Alessio Fasano, MD, “The state of health or the state of disease is the combination between what we are—meaning what genetically makes us the way that we’re engineered—and the environment that’s around us. And the gut is the point of entry in which these two elements meet.”).
92 Cryan, John F. and Timothy G. Dinan. “Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.” Nature Reviews Neuroscience 13 (October 2012): 701-12. https://doi.org/10.1038/nrn3346.
93 Alberts, B., et al. “How Cells Obtain Energy from Food” Molecular Biology of the Cell. 4th ed. (New York: Garland Science; 2002). Available at https://www.ncbi.nlm.nih.gov/books/NBK26882/.
94 Sherwood, Lauralee. Human Physiology, 33-40.
95 Fiebich BL, S Akter and RS Akundi. “The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain,” Front. Cell. Neurosci. 8 (2014):260. https://doi.org/10.3389/fncel.2014.00260.
96 Sherwood, Lauralee. Human Physiology, 33-40.
97 Kharrazian, Datis. Why Isn’t My Brain Working?, 119 (“ATP is the fuel source for all biochemical reactions.”).
98 https://www.lexico.com/definition/nutrient.
99 Sherwood, Lauralee. Human Physiology, 33-40.
100 Ames Bruce N. “Micronutrients prevent cancer and delay aging,” Toxicology Letters 102–103 (28 December 1998): 5-18. https://doi.org/10.1016/S0378-4274(98)00269-0.
101 Ames Bruce N. “Micronutrients prevent cancer and delay aging” 5-18.
102 Cassidy, A. and C. D. Kay. “Phytochemicals” Chapter in Nutrition and Metabolism 2nd ed. (eds S. A. Lanham-New, I. A. Macdonald and H. M. Roche) (Oxford, UK: Wiley-Blackwell, 2010), chapter 14. https://doi.org/10.1002/9781444327779.ch14.
103 Wahls, Terry L. The Wahls Protocol.
104 Vercellino, Marco et al. “Grey Matter Pathology in Multiple Sclerosis,” Journal of Neuropathology & Experimental Neurology 64 (12) (1 December 2005): 1101–107. https://doi.org/10.1097/01.jnen.0000190067.20935.42.
105 Wahls, Terry L. The Wahls Protocol, 7.
106 Wahls, Terry L. The Wahls Protocol, 9-10.
107 See the website of the Institute for Functional Medicine available at https://www.ifm.org/functional-medicine/.
108 https://www.ifm.org/functional-medicine/.
109 Wahls, Terry L. The Wahls Protocol, 9-10.
110 Wahls, Terry L. The Wahls Protocol, 9-10.
111 Berkow, Susan, and Sushma Palmer. “Nutrition in medical education: current status and future directions.” The Journal of Nutrition 116.3 (1986): 341-342.
112 Minger, Denise. Death by Food Pyramid. Primal Blueprint Publishing, 2013.
113 Wahls, Terry L. The Wahls Protocol, 8.
114 Wahls, Terry L. The Wahls Protocol, 11.
115 Wahls, Terry L. The Wahls Protocol, 11.
116 Bender, David A. Introduction to Nutrition and Metabolism, 1-6.
117 Wahls, Terry L. The Wahls Protocol, 11.
118 Wahls, Terry L. The Wahls Protocol, 11.
119 Wahls, Terry L. The Wahls Protocol, 11.
120 Wahls, Terry L. The Wahls Protocol, 12.
121 https://terrywahls.com/about/about-terry-wahls/ .
122 Wahls, Terry L. The Wahls Protocol.
123 Kharrazian, Datis. Why Isn’t My Brain Working?, 199-200.
124 Wahls, Terry L. The Wahls Protocol.
Chapter 3
1 Perlmutter, David E. Grain Brain, 70-84.
2 Nierenberg, Danielle. “Factory farming in The Developing World,” World Watch 16.3 (2003): 10-19.
3 Herrmann, Wolfgang, et al. “Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians., The American Journal of Clinical Nutrition 78.1 (2003): 131-36.
4 Rosell, Magdalena S et al. “Long-chain n–3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men,” The American Journal of Clinical Nutrition 82.2 (2005): 327-334.
5 Dwyer, Johanna T. “Nutritional Consequences of Vegetarianism,” Annual Review of Nutrition 11.1 (1991): 61-91.
6 Hunt, Janet R. “Bioavailability of iron, zinc, and other trace minerals from vegetarian diets,” The American Journal of Clinical Nutrition 78.3 (2003): 633S-639S.
7 Bailes, Julian E. and James D Mills. “Docosahexaenoic acid reduces traumatic axonal injury in a rodent head injury model,” Journal of Neurotrauma 27.9 (2010): 1617-624.
8 Mills, James D et al. “Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model: Laboratory investigation,” Journal of Neurosurgery 114.1 (2011): 77-84.
9 Lewis, Michael, Parviz Ghassemi and Joseph Hibbeln. “Therapeutic use of omega-3 fatty acids in severe head trauma,”The American Journal of Emergency Medicine 31.1 (2013): 273. e5-273. e8.
10 Lewis, Michael, et al. “Therapeutic use of omega-3 fatty acids in severe head trauma” 273. e5-273. e8.
11 Lewis, Michael, et al. “Therapeutic use of omega-3 fatty acids in severe head trauma” 273. e5-273. e8.
12 Damude, Howard G. and Anthony J Kinney. “Engineering oilseed plants for a sustainable, land-based source of long chain polyunsaturated fatty acids,” Lipids 42.3 (2007): 179-185.
13 Haggarty, P et al. “Long-chain polyunsaturated fatty acid transport across the perfused human placenta,” Placenta 18.8 (1997): 635-642.
14 Gerster, H. “Can adults adequately convert alpha-linolenic acid (18: 3n-3) to eicosapentaenoic acid (20: 5n-3) and docosahexaenoic acid (22: 6n-3)?,” International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift fur Vitamin-und Ernährungsforschung. Journal International de Vitaminologie et de Nutrition 68.3 (1997): 159-173.
15 Arterburn, Linda M et al. “Bioequivalence of docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food,” Lipids 42.11 (2007): 1011-024.
16 Doughman, Scott D, Srirama Krupanidhi, and Carani B Sanjeevi. “Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA,” Current Diabetes Reviews 3.3 (2007): 198-203.
17 Conquer, Julie A. and Bruce J Holub. “Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects,” The Journal of Nutrition 126.12 (1996): 3032.
Chapter 4
1 Spruss, Astrid and Ina Bergheim. “Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease,” The Journal of Nutritional Biochemistry 20.9 (2009): 657-662.
2 Gibson, PR, and SJ Shepherd. “Personal view: food for thought–western lifestyle and susceptibility to Crohn’s disease. The FODMAP hypothesis,” Alimentary Pharmacology & Therapeutics 21.12 (2005): 1399-409.
3 Csáki, Katalin F. “Synthetic surfactant food additives can cause intestinal barrier dysfunction,” Medical Hypotheses 76.5 (2011): 676-81.
4 Akoh, Casimir C. and David B Min. Food Lipids: Chemistry, Nutrition, and Biotechnology (Boca Raton: CRC press, 2008).
5 Rose, GA, WB Thomson, and RT Williams. “Corn oil in treatment of ischaemic heart disease,” British Medical Journal 1.5449 (1965): 1531.
6 Moret, Sabrina, A Dudine, and LS Conte. “Processing effects on the polyaromatic hydrocarbon content of grapeseed oil,” Journal of the American Oil Chemists’ Society 77.12 (2000): 1289-292.
7 Body Nutrition. “Grapeseed Oil provides minimal benefits, lacks nutrients.” Retrieved September 10, 2017, from https://bodynutrition.org/grapeseed-oil/.
8 Smith, J. M. “Are Genetically Modified Foods a Gut-Wrenching Combination?” Responsible Technology. Retrieved September 10, 2017, from http://www.responsibletechnology.org/for-review/glutenintroduction/.
9 Kharrazian, Datis, Why Isn’t My Brain Working?, 36, 38, 42-43, 101-102, 175.
10 Perlmutter, David E. Grain Brain, 51, 53, 61-62.
11 Daulatzai, Mak A. “Non-Celiac Gluten Sensitivity Triggers Gut Dysbiosis, Neuroinflammation, Gut-Brain Axis Dysfunction, and Vulnerability for Dementia,” CNS & Neurological Disorders – Drug Targets 14(1) (February 2015): 110-31 (22). Available at https://www.ingentaconnect.com/content/ben/cnsnddt/2014/00000014/00000001/art00018.
12 Kharrazian, Datis. Why Isn’t My Brain Working?, 126-31.
13 Perlmutter, David E. Grain Brain, 21-177.
14 Hollon, Justin et al. “Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity,” Nutrients 7.3 (2015): 1565-576.
15 Hollon, Justin et al. “Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity.” Nutrients 7.3 (2015): 1565-576.
16 Severance, Emily G et al. “Subunit and whole molecule specificity of the anti-bovine casein immune response in recent onset psychosis and schizophrenia.” Schizophrenia Research 118.1 (2010): 240-47.
17 Kharrazian, Datis. Why In’t My Brain Working?, 151-152.
18 Brogan, K., MD. “Two Foods That May Sabotage Your Brain.” Kelly Brogan MD, (2014, May). Retrieved September 10, 2017, from https://kellybroganmd.com/two-foods-may-sabotage-brain/.
19 Kharrazian, Datis,. Why Isn’t My Brain Working?, 126, 151-52.
20 Brogan, K., MD. “Two Foods That May Sabotage Your Brain.” Kelly Brogan MD, (2014, May). Retrieved September 10, 2017, from https://kellybroganmd.com/two-foods-may-sabotage-brain/.
21 Huebner, FR et al. “Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates” Peptides 5.6 (1984): 1139-147.
22 Bansal, Vishal et al. “Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis,” Journal of Neurotrauma 26.8 (2009): 1353-359.
23 Forsyth, Christopher B et al. “Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease,” PlOS ONE 6.12 (2011): e28032.
24 Hamada, Kazuma et al. “Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats,” Cancer Chemotherapy and Pharmacology 66.6 (2010): 1031-038.
25 Bjarnason, Ingvar et al. “Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs,” The Lancet 324.8413 (1984): 1171-174.
26 Fasano, Alessio. “Zonulin and Its Regulation of Intestinal Barrier function: The Biological Door to Inflammation, Autoimmunity, and Cancer,” Physiological Reviews 91.1 (2011): 151-175.
27 Hadjivassiliou, Marios, Clare A Williamson, and Nicola Woodroofe. “The immunology of gluten sensitivity: beyond the gut.” Trends in Immunology25.11 (2004): 578-82.
28 Lundin, Knut EA and Armin Alaedini. “Non-celiac gluten sensitivity,” Gastrointestinal Endoscopy Clinics of North America 22.4 (2012): 723-34.
29 Bernard, H et al. “Molecular basis of IgE cross-reactivity between human β-casein and bovine β-casein, a major allergen of milk.” Molecular Immunology 37.3 (2000): 161-167.
30 Gropper, Sareen S, Jack L Smith, and James L Groff. “Advanced nutrition and human metabolism.” Wadsworth: Wadsworth Cengage Learning (2009).
31 Wahls, Terry L. The Wahls Protocol, 323-25.
32 Wahls, Terry L. The Wahls Protocol, 323-25.
33 Wahls, Terry L. The Wahls Protocol, 323-25.
34 Wahls, Terry L. The Wahls Protocol, 323-25.
35 O’Bryan, Tom. The Autoimmune Fix, 211-87.
36 Kharrazian, Datis. Why Isn’t My Brain Working?, 36-38, 42-43, 101-102, 175.
37 Perlmutter, David E. Grain Brain, 51, 53, 61-62.
38 Brogan, K., MD. “Two Foods That May Sabotage Your Brain.” Kelly Brogan MD, (2014, May). Retrieved September 10, 2017, from https://web.archive.org/web/20200420205346/https://kellybroganmd.com/two-foods-may-sabotage-brain/.
39 Perlmutter, David E. Grain Brain, 126, 151-52.
40 Kharrazian, Datis, Why Isn’t My Brain Working?, 149.
Chapter 5
1 Watts, David L. “Nutrient interrelationships: minerals, vitamins, endocrines,” Journal of Orthomolecular Medicine 5.1 (1990): 11-19.
2 O’Dell, Boyd L. “Mineral interactions relevant to nutrient requirements,” The Journal of Nutrition 119.12 Suppl (1989): 1832-838.
3 O’Shaughnessy, Thomas J, Hsingch J Lin, and Wu Ma. “Functional synapse formation among rat cortical neurons grown on three-dimensional collagen gels,” Neuroscience Letters 340.3 (2003): 169-72.
4 Mahmood A. Aljumaily “The effect of concentrated bone broth as a dietary supplementation on bone healing in rabbits,” Annals of the College of Medicine Mosul 37 (December 2011): 42-47.
5 Ihanamäki, Tapio, Lauri J Pelliniemi, and Eero Vuorio. “Collagens and collagen-related matrix components in the human and mouse eye,” Progress in Retinal and Eye Research 23.4 (2004): 403-34.
6 Reynolds, Edward. “Vitamin B12, folic acid, and the nervous system,” The Lancet Neurology 5.11 (2006): 949-60.
7 Petrucci, Kellyann. Dr. Kellyann’s Bone Broth Diet: Lose Up to 15 Pounds, 4 Inches—and Your Wrinkles!—in Just 21 Days, (New York: Rodale Press, Inc., 2015), 84.
Chapter 6
1 Wahls, Terry L. The Wahls Protocol, 111-12.
2 Wahls, Terry L. The Wahls Protocol, 111-12.
3 Reynolds, Edward. “Vitamin B12, folic acid, and the nervous system,” The Lancet Neurology 5.11 (2006): 949-60.
4 Tang, G. “Bioconversion of dietary provitamin A carotenoids to vitamin A in humans,” Am. J of Clin. Nutrition 91(suppl) (2010): 1468S-1473S. https://doi.org/10.3945/ajcn.2010.28674G.
5 Xiang, Mengqing et al. “Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.” Neuron 11.4 (1993): 689-701.
6 Bender, David A. Introduction to Nutrition and Metabolism, 317-23.
7 Saari, John C et al. “Cellular retinaldehyde‐binding protein is expressed by oligodendrocytes in optic nerve and brain,” Glia 21.3 (1997): 259-68.
8 Kennes, B et al. “Effect of vitamin C supplements on cell-mediated immunity in old people,” Gerontology 29.5 (1983): 305-10.
9 Anderson, R et al. “The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers,” The American Journal of Clinical Nutrition 33.1 (1980): 71-76.
10 Bender, David A. Introduction to Nutrition and Metabolism, 366-71.
11 Ferland, Guylaine. “Vitamin K and the nervous system: an overview of its actions,” Advances in Nutrition: An International Review Journal 3.2 (2012): 204-212.
12 Fan, Ying et al. “A preliminary study on bioactivity of orange and tangerine peel extracts against aphis and mites,” Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China Journal of Chinese Materia Medica 20.7 (1995): 397-8, 446.
13 Wahls, Terry L. The Wahls Protocol, 116-22.
14 Trinh, K., et al. “Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson’s Disease,” J of Neuroscience 28 (2) (January 9, 2008) 465-472. https://doi.org/10.1523/JNEUROSCI.4778-07.2008 Available at http://www.jneurosci.org/content/28/2/465.short.
15 Lucas, SianMarie, Nancy J Rothwell, and Rosemary M Gibson. “The role of inflammation in CNS injury and disease,” British Journal of Pharmacology147.S1 (2006): S232-S240.
16 O’Dwyer, Sarah T et al. “A single dose of endotoxin increases intestinal permeability in healthy humans,” Archives of Surgery 123.12 (1988): 1459-464.
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23 Dolan, RJ et al. “Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment, Journal of Neurology, Neurosurgery & Psychiatry 55.9 (1992): 768-73.
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25 Wahls, Terry L. The Wahls Protocol, 117.
26 Guerrero-Beltrán, Carlos Enrique et al. “Protective effect of sulforaphane against oxidative stress: recent advances,” Experimental and Toxicologic Pathology 64.5 (2012): 503-508.
27 Wahls, Terry L. The Wahls Protocol, 121.
28 Bianchini, Franca and Harri Vainio. “Allium vegetables and organosulfur compounds: Do they help prevent cancer?” Environmental Health Perspectives109.9 (2001): 893.
29 Takahashi, Mizuho and Takayuki Shibamoto. “Chemical compositions and antioxidant/anti-inflammatory activities of steam distillate from freeze-dried onion (Allium cepa L.) sprout,” Journal of Agricultural and Food Chemistry 56.22 (2008): 10462-10467.
30 Borek, Carmia. “Garlic reduces dementia and heart-disease risk,” The Journal of Nutrition 136.3 (2006): 810S-812S.
31 Wahls, Terry L. The Wahls Protocol, 119.
32 Wahls, Terry L. The Wahls Protocol, 117, 119, 287.
33 Wahls, Terry L. The Wahls Protocol, 287.
34 Lull, Cristina, Harry J Wichers, and Huub FJ Savelkoul. “Antiinflammatory and immunomodulating properties of fungal metabolites,” Mediators of Inflammation 2005.2 (2005): 63-80.
35 Akramiene, Dalia et al. “Effects of beta-glucans on the immune system,” Medicina (Kaunas, Lithuania) 43.8 (2006): 597-606.
36 Wahls, Terry L. The Wahls Protocol, 120.
37 Wahls, Terry L. The Wahls Protocol, 113-14.
38 Wahls, Terry L. The Wahls Protocol, 114.
39 Wahls, Terry L. The Wahls Protocol, 114.
40 Wahls, Terry L. The Wahls Protocol, 142.
41 Ames, Bruce N, Mark K Shigenaga, and Tory M Hagen. “Oxidants, antioxidants, and the degenerative diseases of aging,” Proceedings of the National Academy of Sciences 90.17 (1993): 7915-922.
42 Ames, Bruce N, Mark K Shigenaga, and Tory M Hagen. “Oxidants, antioxidants, and the degenerative diseases of aging” 7915-922.
43 Ames, Bruce N, Mark K Shigenaga, and Tory M Hagen. “Oxidants, antioxidants, and the degenerative diseases of aging” 7915-922.
44 Ames, Bruce N, Mark K Shigenaga, and Tory M Hagen. “Oxidants, antioxidants, and the degenerative diseases of aging” 7915-922.
45 Slemmer, Jennifer E et al. “Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging,” Current Medicinal Chemistry 15.4 (2008): 404-14.
46 Giunta, Brian et al. “The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention,” Journal of Neuroinflammation 9.1 (2012): 185.
47 Shao, ChangXing et al. “Oxidative stress in head trauma in aging,” Free Radical Biology and Medicine 41.1 (2006): 77-85.
48 Watzl, Bernhard. “Anti-inflammatory effects of plant-based foods and of their constituents,” International Journal for Vitamin and Nutrition Research78.6 (2008): 293-298.
49 Youdim, Kuresh A. and James A. Joseph. “A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects,” Free Radical Biology and Medicine 30.6 (2001): 583-94.
50 Webb, Andrew J et al. “Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite,” Hypertension 51.3 (2008): 784-90.
51 The Institute of Functional Medicine “Phytonutrient-Spectrum-Comprehensive-Guide” (2014). Retrieved on 30 Apr. 2016 http://www.thehealthedgepodcast.com/wp-content/uploads/2015/07/Phytonutrient-Spectrum-Comprehensive-Guide.pdf.
52 Wahls, Terry L. The Wahls Protocol, 372.
53 Wahls, Terry L. The Wahls Protocol, 373.
54 Wahls, Terry L. The Wahls Protocol, 374.
55 Wahls, Terry L. The Wahls Protocol, 374.
56 Wahls, Terry L. The Wahls Protocol, 116.
57 Münch, Gerald et al. “Advanced glycation endproducts and their pathogenic roles in neurological disorders,” Amino Acids 42.4 (2012): 1221-236.
58 Emanuele, Enzo et al. “Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia,” Archives of Neurology 62.11 (2005): 1734-736.
59 Coker, Laura H. and Lynne E. Wagenknecht. “Advanced glycation end products, diabetes, and the brain,” Neurology 77.14 (2011): 1326-327.
60 Curtis, TM et al. “Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products,” Diabetologia 54.3 (2011): 690-98.
61 Batty, G David et al. “IQ in early adulthood and mortality by middle age: cohort study of 1 million Swedish men,” Epidemiology 20.1 (2009): 100-09.
62 Scheele, Camilla et al. “Altered regulation of the PINK1 locus: a link between Type 2 diabetes and neurodegeneration?” The FASEB Journal 21.13 (2007): 3653-665.
63 Suzanne, M. and Jack R Wands. “Alzheimer’s disease is Type 3 diabetes—evidence reviewed.” Journal of Diabetes Science and Technology 2.6 (2008): 1101-113.
64 Kharrazian, Datis. Why Isn’t My Brain Working?, 71.
65 Permlutter, David E. Grain Brain, 27-31.
66 Kharrazian, Datis.Why Isn’t My Brain Working?, 59-71.
67 Suh, Sang Won et al. “Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase,” The Journal of Clinical Investigation 117.4 (2007): 910-18.
68 Kharrazian, Datis. Why Isn’t My Brain Working?, 63-64.
69 Kikuchi, Seiji et al. “Glycation—a sweet tempter for neuronal death., Brain Research Reviews 41.2 (2003): 306-23.
70 Kikuchi, Seiji et al. “Glycation—a sweet tempter for neuronal death” 306-323.
71 Perlmutter, David E. Grain Brain, 113-14.
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74 Munck, Allan, and Seymour B Koritz. “Studies on the mode of action of glucocorticoids in rats I. Early effects of cortisol on blood glucose and on glucose entry into muscle, liver and adiposèttissue,” Biochimica et Biophysica Acta 57.1 (1962): 310-17.
75 Weitzman, Elliot D et al. “Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects,” The Journal of Clinical Endocrinology & Metabolism 33.1 (1971): 14-22.
76 Rizza, Robert A, Lawrence J Mandarino, and John E Gerich. “Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action,” The Journal of Clinical Endocrinology & Metabolism 54.1 (1982): 131-38.
77 Bolton, Robin P, Kenneth W Heaton, and Lennard F Burroughs. “The role of dietary fiber in satiety, glucose, and insulin: studies with fruit and fruit juice,” The American Journal of Clinical Nutrition 34.2 (1981): 211-17.
78 The NIH HMP Working Group, “The NIH Human Microbiome Project” Genome Res. 19 (2009): 2317-2323. Also available online at https://doi.org/10.1101/gr.096651.109.
79 Wikipedia, “Human Microbiome Project” availabe at https://en.wikipedia.org/wiki/Human_Microbiome_Project.
80 Arthur, Benjamin and Rob Stein. “Exploring The Invisible Universe That Lives On Us — And In Us,” National Public Radio (November 4, 2013). Retrieved on September 29, 2017 from https://www.npr.org/sections/health-shots/2013/11/01/242361826/exploring-the-invisible-universe-that-lives-on-us-and-in-us. Part of an NPR special series called The Human Microbiome: Guts and Glory ( http://www.npr.org/series/218987212/microbiome).
81 Pflughoeft, Kathryn J. and James Versalovic. “Human microbiome in health and disease,” Annual Review of Pathology: Mechanisms of Disease 7 (2012): 99-122.
82 Gerritsen, Jacoline et al. “Intestinal microbiota in human health and disease: the impact of probiotics.” Genes & Nutrition 6.3 (2011): 209-40.
83 Wahls, Terry. The Wahls Protocol, 90.
84 Wahls, Terry. The Wahls Protocol, 90.
85 McFall-Ngai, M., et al. “Animals in a bacterial world, a new imperative for the life sciences,” PNAS 110 (9) (2013): 3229-236; published ahead of print February 7, 2013, doi:10.1073/pnas.1218525110.
86 Velasquez-Manoff, M. “Fruits and Vegetables Are Trying to Kill You,” Nautilus, (2014, July 17). http://nautil.us/issue/15/turbulence/fruits-and-vegetables-are-trying-to-kill-you.
87 Mattson, Mark P. and Aiwu Cheng. “Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses,” Trends in Neurosciences 29.11 (2006): 632-39.
88 Mattson, Mark P. and Aiwu Cheng. “Neurohormetic phytochemicals” 632-39.
Chapter 7
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2 Ng, Marie, et al. “Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A Systematic Analysis for the Global Burden of Disease Study 2013,” The Lancet 384.9945 (2014): 766-81.
3 asior, Maciej, Michael A Rogawski, and Adam L Hartman. “Neuroprotective and disease-modifying effects of the ketogenic diet,” Behavioural Pharmacology 17.5-6 (2006): 431.
4 Maalouf, Marwan, Jong M Rho, and Mark P Mattson. “The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.” Brain Research Reviews 59.2 (2009): 293-315.
5 Neuringer, Martha and William E. Connor. “N-3 Fatty Acids in the Brain and Retina: Evidence for Their Essentiality,” Nutrition Reviews 44.9 (2009): 285-94.
6 Haag, Marianne. “Essential fatty acids and the brain.” Canadian Journal of Psychiatry. Revue Cnadienne de Psychiatrie 48.3 (2003): 195-203.
7 Wainwright, Patricia E. “Dietary essential fatty acids and brain function: a developmental perspective on mechanisms.” Proceedings of the Nutrition Society 61.01 (2002): 61-69.
8 Innis, Sheila M. “Dietary (n-3) fatty acids and brain development,” The Journal of Nutrition 137.4 (2007): 855-59.
9 Center for Disease Control and Prevention. “CDC Prevention Guidelines.” Public Health Service, (1989, October 01). Retrieved September 11, 2017, from https://wonder.cdc.gov/wonder/prevguid/p0000109/p0000109.asp.
10 Cunnane, S. C., & Crawford, M. A. “Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution.” J of Human Evolution, 77 (2014): 88-98. https://doi.org/10.1016/j.jhevol.2014.05.001.
11 Perlmutter, David E. Grain Brain. 185-186.
12 Barañano K.W. and Hartman, A.L. “The ketogenic diet: uses in epilepsy and other neurologic illnesses,” Curr Treat Options Neurol. 10(6)(2008 Nov): 410-19.
13 Farooqui, A., et al. “Modulation of inflammation in brain: a matter of fat,” J of Neurochemistry, 101(3) (2006): 577-99. https://doi.org/10.1111/j.1471-4159.2006.04371.x.
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16 Sejian, V., Maurya, V. P., and Naqvi, S. M. “Adaptive capability as indicated by endocrine and biochemical responses of Malpura ewes subjected to combined stresses (thermal and nutritional) in a semi-arid tropical environment.” Intl J of Biometeorology, 54(6) (2010): 653-61. httpS://doi.org/10.1007/s00484-010-0341-1.
17 Reger, Mark A et al. “Effects of β-hydroxybutyrate on cognition in memory-impaired adults,” Neurobiology of Aging 25.3 (2004): 311-14.
18 Gasior, Maciej, Michael A Rogawski, and Adam L Hartman. “Neuroprotective and disease-modifying effects of the ketogenic diet,” Behavioural Pharmacology 17.5-6 (2006): 431.
19 Morris, Martha Clare et al. “Dietary fats and the risk of incident Alzheimer disease,” Archives of Neurology 60.2 (2003): 194-200.
20 Vanitallie, TB et al. “Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study,” Neurology 64.4 (2005): 728-30.
21 Prins, ML, LS Fujima, and DA Hovda. “Age dependent reduction of cortical contusion volume by ketones after traumatic brain injury,” Journal of Neuroscience Research 82.3 (2005): 413-20.
22 Yamada, Kelvin A., Nicholas Rensing, and Liu Lin Thio. “Ketogenic diet reduces hypoglycemia-induced neuronal death in young rats,” Neuroscience Letters 385.3 (2005): 210-14.
23 Swink, Traci D., EP Vining, and John M. Freeman. “The Ketogenic Diet: 1997,” Advances in Pediatrics 44 (1996): 297-329.
24 Stafstrom, C.E. and Rho, J.M. “The Ketogenic Diet as a Treatment for Diverse Neurological Disorders,” Frontiers in Pharmaology 3 (2012): 59.
25 BreakNutrition. “What is the keto flu or low carb flu and what to do about it?” (September 19, 2017). Retrieved September 30, 2017, from https://nutrita.app/keto-flu/.
26 Wilson, J. M. and Lowery, R. The Ketogenic Bible: The Authoritative Guide to Ketosis (Las Vegas: Victory Belt Publishing, 2017).
27 Kalamian, M. Keto for Cancer: Ketogenic Metabolic Therapy as a Targeted Nutritional Strategy (White River Junction, VT: Chelsea Green Publishing, 2017), 27.
28 de Souza, Russell J et al. “Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and Type 2 diabetes: systematic review and meta-analysis of observational studies,” BMJ 351 (2015): h3978.
29 Chowdhury, Rajiv et al. “Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis.” Annals of Internal Medicine 160.6 (2014): 398-406.
30 Schwab, Ursula et al. “Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing Type-2 diabetes, cardiovascular disease, and cancer: a systematic review,” Food & Nutrition Research 58 (2014).
31 Walsh, B. “Ending the War on Fat.” Time Magazine, 183(24) (2014, June 23).
32 Okie, Susan. “New York to trans fats: you’re out!” New England Journal of Medicine 356.20 (2007): 2017-021.
33 Mozaffarian, Dariush et al. “Trans fatty acids and cardiovascular disease,” New England Journal of Medicine 354.15 (2006): 1601-613.
34 Kummerow, Fred A. “The negative effects of hydrogenated trans fats and what to do about them.” Atherosclerosis 205.2 (2009): 458-65.
35 Przybylski, Roman, et al. “Canola oil.” Chapter 2 of Bailey’s Industrial Oil & Fat Products: Volume 2: Edible oil and fat products: edible oils, ed. Fereidoon Shahidi (Hoboken, NJ: John Wiley & Sons, 2005), 61-121. https://doi.org/10.1002/047167849X.bio004.
36 Finkelstein, Israel and Neil Asher Silberman. David and Solomon: In Search of the Bible’s Sacred Kings and the Roots of the Western Tradition (New York: Free Press, 2006), 131, 317.
37 Covas, María-Isabel et al. “Minor components of olive oil: evidence to date of health benefits in humans,” Nutrition Reviews 64. suppl 4 (2006): S20-S30.
38 Fulgoni, V. L., Dreher, M., and Davenport, A. J. “Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001–2008,” Nutrition Journal 12(1) (2013). https://doi.org/10.1186/1475-2891-12-1.
39 Ogbolu, DO et al. “In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria,” Journal of Medicinal Food 10.2 (2007): 384-387.
40 Esterbauer, Hermann. “Cytotoxicity and genotoxicity of lipid-oxidation products,” The American Journal of Clinical Nutrition 57.5 (1993): 779S-785S.
41 Alexander, JC. “Chemical and biological properties related to toxicity of heated fats,” Journal of Toxicology and Environmental Health, Part A Current Issues 7.1 (1981): 125-38.
42 Staprans, Ilona et al. “Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum.” Arteriosclerosis, Thrombosis, and Vascular Biology 14.12 (1994): 1900-905.
43 Jaarin, Kamsiah and Yusof Kamisah. “Repeatedly Heated Vegetable Oils and Lipid Peroxidation.” Lipid Peroxidation, 2012. https://doi.org/10.5772/46076.
44 Addis, PB. “Occurrence of lipid oxidation products in foods.” Food and Chemical Toxicology 24.10 (1986): 1021-030.
45 Przybylski, Roman et al. “Canola oil,” Bailey’s Industrial Oil and Fat Products (2005).
46 Taubes, Gary. Good calories, bad calories: Fats, carbs, and the controversial science of diet and health. (New York: Anchor Books, 2008).
47 Johnstone, Alexandra M et al. “Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum,” The American Journal of Clinical Nutrition 87.1 (2008): 44-55.
48 Sondike, Stephen B, Nancy Copperman, and Marc S Jacobson. “Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents,” The Journal of Pediatrics 142.3 (2003): 253-58.
49 Cholesterol Numbers video on Mayo Clinic website. Retrieved November 23, 2017 from https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/diagnosis-treatment/drc-20350806.
50 Gasior, Maciej, Michael A. Rogawski, and Adam L. Hartman. “Neuroprotective and disease-modifying effects of the ketogenic diet,” Behavioural Pharmacology 17.5-6 (2006): 431.
51 Elias, Ellen, et al. “Clinical effects of cholesterol supplementation in six patients with the Smith-Lemli-Opitz syndrome (SLOS),” American Journal of Medical Genetics (1997): 305-10.
52 Elias, Ellen, et al. “Clinical effects of cholesterol supplementation in six patients with the Smith-Lemli-Opitz syndrome (SLOS)” 305-10.
53 Elias, Ellen, et al. “Clinical effects of cholesterol supplementation in six patients with the Smith-Lemli-Opitz syndrome (SLOS)” 305-10.
54 Davison, Karen M., and Bonnie J. Kaplan. “Lipophilic Statin Use and Suicidal Ideation in a Sample of Adults With Mood Disorders,” Crisis 35.4 (2014): 278-82.
55 Hanukoglu, Israel. “Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone biosynthesis,” The Journal of Steroid Biochemistry and Molecular Biology (1992): 779-804.
56 Perlmutter, David E. Grain Brain, 93-98.
57 Perlmutter, David. E. Grain Brain, 91.
58 Pfrieger, Frank. “Role of cholesterol in synapse formation and function,” Biochimica et Biophysica Acta (BBA) – Biomembranes (2003): 271-80.
59 Pfrieger, Frank. “Role of cholesterol in synapse formation and function” 271-80.
60 Baron, Stephen and Phillip Hylemon. “Biotransformation of Bile Acids, Cholesterol, and Steroid Hormones.” Gastrointestinal Microbiology (1997): 470-510.
61 Perlmutter, David E. Grain Brain, 91-93.
62 Sachinidis, A., R. Kettenhofen, S. Seewald, I. Gouni-Berthold, U. Schmitz, C. Seul, Y. Ko, and H. Vetter “Evidence That Lipoproteins Are Carriers of Bioactive Factors.” Arteriosclerosis, Thrombosis, and Vascular Biology (1999): 2412-421.
63 Perlmutter, David E. Grain Brain, 92, 100-102.
64 341 Perlmutter, David E. Grain Brain, 91.
65 Koenig, W. et al. “C-reactive protein, a sensitive marker for inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men,” Journal of Cardiothoracic and Vascular Anesthesia (1999): 237-42.
66 Koenig, W. et al. “C-reactive protein, a sensitive marker for inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men” 237-42.
67 Datta, Subinay, Zahidul Iqbal, and K.R. Prasad. “Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease,” Indian Journal of Clinical Biochemistry (2011): 210-13.
68 Datta, Subinay, Zahidul Iqbal, and K.R. Prasad. “Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease,” Indian Journal of Clinical Biochemistry (2011): 210-13.
69 Fernandez, Maria. “Rethinking dietary cholesterol.” Current Opinion in Clinical Nutrition and Metabolic Care (2012): 117-21.
70 Perlmutter, David E. Grain Brain, 98-100.
71 Perlmutter, David E. Grain Brain, 93-100.
72 Perlmutter, David E. Grain Brain, 93-100.
73 Kannappan, Ramaswamy et al. “Neuroprotection by spice-derived nutraceuticals: you are what you eat!.” Molecular Neurobiology 44.2 (2011): 142-59.
74 Singletary, Keith. “Black pepper: overview of health benefits,” Nutrition Today 45.1 (2010): 43-47.
Chapter 8
1 Elkaim, Y. “The Truth About How Much Water You Should Really Drink.” (September 13, 2013). Retrieved September 30, 2017, from https://health.usnews.com/health-news/blogs/eat-run/2013/09/13/the-truth-about-how-much-water-you-should-really-drink.
2 Prentice, A. (2005). “Macronutrients as sources of food energy,” Public Health Nutrition, 8(7a), 932-39. https://doi.org/10.1079/PHN2005779.
3 Wahls, Terry L. The Wahls Protocol, 197.
Chapter 9
1 Pfrieger, Frank W. “Role of cholesterol in synapse formation and function,” Biochimica et Biophysica Acta (BBA)-Biomembranes 1610.2 (2003): 271-80.
2 Kharrazian, Datis. Why Isn’t My Brain Working?, 28-30.
3 Kharrazian, Datis. Why Isn’t My Brain Working?, 22-26, 30-31.
4 Wurtman, Richard J et al. “Use of phosphatide precursors to promote synaptogenesis,” Annual Review of Nutrition 29 (2009): 59-87.
5 Wurtman, Richard J. “Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses,” Frontiers in Psychiatry 1 (2010).
6 Blusztajn, Jan K, and Richard J Wurtman. “Choline biosynthesis by a preparation enriched in synaptosomes from rat brain.” Nature 290.5805 (1981): 417-18.
7 Wurtman, Richard J. “A nutrient combination that can affect synapse formation, Nutrients 6.4 (2014): 1701-710.
8 Wurtman, Richard J. et al. “Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses,” Nutrition Reviews 68. suppl 2 (2010): S88-S101.
9 Wurtman, Richard J. et al. “Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally,” Brain Research 1088.1 (2006): 83-92.
10 Wurtman, Richard J. et al. “Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally” 83-92.
11 Blalock, T. “Citicoline Vs. Choline.” Livestrong, (October 11, 2015). Retrieved September 10, 2017, from http://www.livestrong.com/article/478224-citicoline-vs-choline/.
12 Hasselmo, Michael E. “Neuromodulation and cortical function: modeling the physiological basis of behavior,” Behavioural Brain Research 67.1 (1995): 1-27.
13 Hasselmo, Michael E. “Neuromodulation and cortical function: modeling the physiological basis of behavior” 1-27.
14 Teather, Lisa A, and Richard J Wurtman. “Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats,” Learning & Memory 12.1 (2005): 39-43.
15 Baskaya, Mustafa K et al. “Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury,” Journal of Neurosurgery 92.3 (2000): 448-52.
16 EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. “Scientific Opinion on the safety of “citicoline” as a Novel Food ingredient,” EFSA Journal 11 (10) (2013):3421-22 https://doi.org/10.2903/j.efsa.2013.3421.
17 Lewis, Michael, Parviz Ghassemi, and Joseph Hibbeln. “Therapeutic use of omega-3 fatty acids in severe head trauma,” The American Journal of Emergency Medicine 31.1 (2013): 273. e5-273. e8.
18 Lewis, Michael D. and Julian Bailes. “Neuroprotection for the warrior: dietary supplementation with omega-3 fatty acids,” Military Medicine 176.10 (2011): 1120-127.
19 Hasadsri, L., et al. “Omega-3 Fatty Acids as a Putative Treatment for Traumatic Brain Injury, Journal of Neurotrauma 30(11) (2013): 897-906. https://doi.org/10.1089/neu.2012.2672.
20 Wurtman, Richard J et al. “Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally,” Brain Research 1088.1 (2006): 83-92.
21 Saydoff-Rolando, Joel, et al. “Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington’s disease,” Neurobiology of Disease 24 (3) (2006): 455-65. https://doi.org/10.1016/j.nbd.2006.08.011.
22 Ratey, John J. A User’s Guide to the Brain: Perception, Attention, and the Four Theatres of the Brain (New York: Vintage Books, 2001).
23 Wurtman, Richard J et al. “Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally,” Brain Research 1088.1 (2006): 83-92.
24 Yu, VY. “The role of dietary nucleotides in neonatal and infant nutrition,” Singapore Medical Journal 39.4 (1998): 145-50.
25 Carr, Daniel O, and Santiago Grisolia. “Incorporation of dihydrouridine monophosphate and uridine monophosphate into liver and brain ribonucleic acid,” Journal of Biological Chemistry 239.1 (1964): 160-66.
26 Borzelleca, J. F. “A Critical Evaluation of the Available Information on the Toxicity/Safety of Orally Administered Uridine.” United States Food & Drug Administration, (2002, June 11). Retrieved September 10, 2017, fromhttps://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0182-02-tab-01-01-vol134-web.pdf.
Chapter 10
1 Wahls, Terry L. The Wahls Protocol, 174.
2 Williams, Peter. “Nutritional composition of red meat,” Nutrition & Dietetics 64.s4 (2007): S113-S119.
3 Wahls, Terry L. The Wahls Protocol, 184.
4 Chilton, Stephanie N, Jeremy P Burton, and Gregor Reid. “Inclusion of fermented foods in food guides around the world,” Nutrients 7.1 (2015): 390-404.
5 David, Lawrence A., et al. “Diet rapidly and reproducibly alters the human gut microbiome”, Nature 505.7484 (2014): 559-63.
6 David, Lawrence A., et al. “Diet rapidly and reproducibly alters the human gut microbiome” 559-63.
7 Tascher, J. “Sauerkraut: The Most Misunderstood Health Food.” Bottom Line Inc, (2017, February 22). RetrievedSeptember 10, 2017, from http://bottomlineinc.com/life/food/sauerkraut-the-most-misunderstood-health-food.
8 Parvez, S et al. “Probiotics and their fermented food products are beneficial for health,” Journal of Applied Microbiology 100.6 (2006): 1171-185.
9 Prohaska, Joseph R. “Functions of trace elements in brain metabolism,” Physiological Reviews 67.3 (1987): 858-901.
10 Knudsen, Nils et al. “Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status,” European Journal of Endocrinology 143.4 (2000): 485-91.
11 Doyle, M. “Iodine: The Forgotten Nutrient.” Blueprint Fitness, (2009, December 11). Accessed September 10, 2017, from http://www.blueprintfitness.co.uk/iodine-the-forgotten-nutrient/.
12 Wahls, Terry L. The Wahls Protocol, 170.
13 Wahls, Terry L. The Wahls Protocol, 169.
14 Skoryna, Stanley C, TM Paul, and Deirdre Waldron Edward. “Studies on inhibition of intestinal absorption of radioactive strontium: I. Prevention of absorption from ligated intestinal segments,” Canadian Medical Association Journal 91.6 (1964): 285.
15 Skoryna, Stanley C, et al.. “Studies on inhibition of intestinal absorption of radioactive strontium” 285.
16 Wahls, Terry L. The Wahls Protocol, 171.
17 Wahls, Terry L. The Wahls Protocol, 172.
18 Wahls, Terry L. The Wahls Protocol, 150.
19 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health,” JAMA 296(15) (2006): 1885-899. https://doi.org/10.1001/jama.296.15.1885.
20 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
21 401 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
22 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
23 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
24 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
25 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
26 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
27 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
28 Mozaffarian, D. and Rimm, E. “Fish Intake, Contaminants, and Human Health” 1885-899.
Chapter 12
1 Fallon, A. “‘Local’ food labeling misleads consumers, regulator reveals,” The Guardian, (2011, February 25). Retrieved September 10, 2017, from http://www.theguardian.com/environment/2011/feb/26/local-food-labelling-misleading-consumers.
2 “Use of the Term Natural on Food Labeling.” Food and Drug Administration (2018). Retrieved on February 27, 2020, from https://www.fda.gov/food/food-labeling-nutrition/use-term-natural-food-labeling.
3 “Use of the Term Natural on Food Labeling.” Food and Drug Administration (2018). Retrieved on February 27, 2020, from https://www.fda.gov/food/food-labeling-nutrition/use-term-natural-food-labeling.
4 “Use of the Term Natural on Food Labeling.” Food and Drug Administration (2018). Retrieved on February 27, 2020, from https://www.fda.gov/food/food-labeling-nutrition/use-term-natural-food-labeling.
5 OrganicAuthority.com. “5 Food Labels That Mean Nothing.” Huffington Post, (January 12, 2012). Retrieved September 10, 2017, from http://www.huffingtonpost.com/organic-authoritycom/5-food-labels-that-mean-n_b_1202681.html.
6 OrganicAuthority.com. “5 Food Labels That Mean Nothing.” Huffington Post, (2012, January 12). Retrieved September 10, 2017, from http://www.huffingtonpost.com/organic-authoritycom/5-food-labels-that-mean-n_b_1202681.html.
7 United States Department of Agriculture. “Meat and Poultry Labeling Terms”. (n.d.). Retrieved September 10, 2017, from https://www.fsis.usda.gov/wps/portal/fsis/topics/food-safety-education/get-answers/food-safety-fact-sheets/food-labeling/meat-and-poultry-labeling-terms/!ut/p/a1/jVJtb4IwEP4t-wDfoEWc0SVkIWxmuokxZhvyZSlwvBigrC0S9-tHWTRq1Nmmues9z13b54p85CG_JJssISKjJcnl3h984QU.
8 The Humane Society of the United States. “How to Read Meat and Dairy Labels.” (n.d.). Retrieved September 10, 2017, from http://www.humanesociety.org/issues/confinement_farm/facts/meat_dairy_labels.html.
9 One Green Planet. “Think You Know ‘Free-Range’ and ‘Cage Free’ Chicken? Think Again.” (2015, November 13). Retrieved September 10, 2017, from /https://www.onegreenplanet.org/animalsandnature/think-you-know-free-range-and-cage-free-chicken-think-again/ .
10 Séralini, Gilles-Eric, et al. “Answers to critics: Why there is a long term toxicity due to a Roundup-tolerant genetically modified maize and to a Roundup herbicide,” Food and Chemical Toxicology 53 (2013): 476-483.
11 Séralini, Gilles-Eric, et al. “Answers to critics” 476-83.
12 Schütte, G. et al. “Herbicide resistance and biodiversity: agronomic and environmental aspects of genetically modified herbicide-resistant plants,” Environmental Sciences Europe 29:5 (2017). Retrieved September 23, 2017 from https://doi.org/10.1186/s12302-016-0100-y.
13 Schütte, G. et al. “Herbicide resistance and biodiversity.”
14 University of California, San Diego. “How Does Bt Work.” Retrieved September 10, 2017, from http://www.bt.ucsd.edu/how_bt_work.html(This website is created and maintained by the Aroian lab at University of California San Diego, which studies Bt (bacillus thuringiensis)).
15 Mesnage, R et al. “Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide,” Journal of Applied Toxicology 33.7 (2013): 695-99.
16 Johnson, D., and O’Connor, S. “These Charts Show Every Genetically Modified Food People Already Eat in the U.S.” Time Magazine, (2015, April 30). Retrieved September 10, 2017, from https://time.com/3840073/gmo-food-charts/.
17 Fernandez-Cornejo, Jorge, Seth Wechsler, Mike Livingston, Lorraine Mitchell. “Genetically Engineered Crops in the United States.” SSRN Electronic Journal (2014).
18 Aldai, Noelia et al. “Length of concentrate finishing affects the fatty acid composition of grass-fed and genetically lean beef: an emphasis on trans-18: 1 and conjugated linoleic acid profiles,” Animal: An International Journal of Animal Bioscience 5.10 (2011): 1643.
Chapter 13
1 Takeuchi, Masayoshi, and Sho-ichi Yamagishi. “Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer’s disease,” Current Pharmaceutical Design 14.10 (2008): 973-978.
2 O’Keefe, Sean et al. “Levels of Trans Geometrical Isomers of Essential Fatty Acids in Some UnhydrogenatedU.S. Vegetable Oils,” Journal of Food Lipids1.3 (1994): 165-176.
3 Rackis, J. J., M.R. Gumbmann, and I.E. Liener. “The USDA trypsin inhibitor study. I. Background, objectives, and procedural details,” Qualitas Plantarum Plant Foods for Human Nutrition 35(3) (1985): 213-42. https://doi.org/10.1007/bf01092196.
4 Lewis, Michael, Parviz Ghassemi, and Joseph Hibbeln. “Therapeutic use of omega-3 fatty acids in severe head trauma,” The American Journal of Emergency Medicine 31.1 (2013): 273. e5-273. e8.
5 Schoenfeld, Laura. “The Use of Blenderized Tube Feeding in Pediatric Patients: Evidence and Guidelines for Dietetic Practice” (Chapel Hill, North Carolina).” 5 Dec. 2013.
6 Escuro, Arlene A. “Blenderized tube feeding: suggested guidelines to clinicians,” Practical Gastroenterology (2014).
7 Schoenfeld, Laura. “The Use of Blenderized Tube Feeding in Pediatric Patients: Evidence and Guidelines for Dietetic Practice (Chapel Hill, North Carolina).” 5 Dec. 2013.
8 Schoenfeld, Laura. “The Use of Blenderized Tube Feeding in Pediatric Patients: Evidence and Guidelines for Dietetic Practice (Chapel Hill, North Carolina).” 5 Dec. 2013.
9 Meier, R. F., Reddy, B. R., and Soeters, P. B., editors. The Importance of Nutrition as an Integral Part of Disease Management. (New York: Karger, 2015), 1.
Chapter 14
1 Spruss, Astrid, and Ina Bergheim. “Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease,” The Journal of Nutritional Biochemistry 20.9 (2009): 657-62.
2 Gibson, PR, and SJ Shepherd. “Personal view: food for thought–western lifestyle and susceptibility to Crohn’s disease. The FODMAP hypothesis,” Alimentary Pharmacology & Therapeutics 21.12 (2005): 1399-409.
3 Csáki, Katalin F. “Synthetic surfactant food additives can cause intestinal barrier dysfunction,” Medical Hypotheses 76.5 (2011): 676-81.
4 Rose, GA, WB Thomson, and RT Williams. “Corn oil in treatment of ischaemic heart disease,” British Medical Journal 1.5449 (1965): 1531.
5 Fernandez-Cornejo, Jorge, Seth Wechsler, Mike Livingston, Lorraine Mitchell. “Genetically Engineered Crops in the United States,” SSRN Electronic Journal (2014).
6 Akoh, Casimir C. and David B Min. Food Lipids: Chemistry, Nutrition, and Biotechnology (Boca Raton: CRC press, 2008).
7 Severance, Emily G et al. “Subunit and whole molecule specificity of the anti-bovine casein immune response in recent onset psychosis and schizophrenia,” Schizophrenia Research 118.1 (2010): 240-247.
8 Severance, Emily G et al. “Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder,” Bipolar Disorders 16.3 (2014): 230-40.
9 Hollon, Justin et al. “Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity,” Nutrients 7.3 (2015): 1565-576.
10 Hadjivassiliou, Marios et al. “Gluten sensitivity: from gut to brain,” The Lancet Neurology 9.3 (2010): 318-30.
11 Lê, Khanh-Tuoc et al. “Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system,” FEBS letters 418.1 (1997): 195-199.
12 Samaroo, Diana et al. “Novel immune response to gluten in individuals with schizophrenia,” Schizophrenia Research 118.1 (2010): 248-255.
13 Lewis, Michael, Parviz Ghassemi, and Joseph Hibbeln. “Therapeutic use of omega-3 fatty acids in severe head trauma.” The American Journal of Emergency Medicine 31.1 (2013): 273. e5-273. e8.
14 Wurtman, Richard J. et al. “Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally,” Brain Research 1088.1 (2006): 83-92.
FAQ
1 Dafny, N. and NR Pellis. “Evidence that opiate addiction is in part an immune response: destruction of the immune system by irradiation-altered opiate withdrawal.” Neuropharmacology 25.8 (1986): 815-18.
2 Kharrazian, Datis. Why Isn’t My Brain Working?, 126-160.
3 Kharrazian, Datis. Why Isn’t My Brain Working?, 128.
4 Davis, D. “Is gluten on the increase?” Wheat Belly (2013, February 15). Retrieved September 10, 2017, from http://www.wheatbellyblog.com/2013/02/is-gluten-on-the-increase/
5 Morell, S. F. “Broth is Beautiful.” The Weston A. Price Foundation, (2000, January 1). Retrieved September 10, 2017, from https://www.westonaprice.org/health-topics/food-features/broth-is-beautiful/.
6 Toledo, Romeo T. “Postprocessing changes in aseptically packed beverages,” Journal of Agricultural and Food Chemistry 34.3 (1986): 405-08.
7 Buchowski, MS et al. “Heating and the distribution of total and heme iron between meat and broth,” Journal of Food Science 53.1 (1988): 43-45.
8 Wahls, Terry L. The Wahls Protocol, 323-25.
9 O’Bryan, Tom, Autoimchapmune Fix, 211-287.
10 Kharrazian, Datis. Why Isn’t My Brain Working?, 95-100.
11 Mönnikes, H et al. “Role of stress in functional gastrointestinal disorders,” Digestive Diseases 19.3 (2001): 201-11.
12 Bockelmann, B. A., & Bockelmann, I. L. “Aseptic packaging of liquid food products: a literature review,” Journal of Agricultural and Food Chemistry, 34(3) (1986): 384-92. doi:10.1021/jf00069a001.